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BRL-15572 dihydrochloride
CAS No. 193611-72-2
BRL-15572 dihydrochloride( BRL15572 | BRL 15572 )
Catalog No. M13033 CAS No. 193611-72-2
BRL-15572 is a potent, selective h5-HT1D receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
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| 10MG | 59 | In Stock |
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| 25MG | 97 | In Stock |
|
| 50MG | 149 | In Stock |
|
| 100MG | 223 | In Stock |
|
| 200MG | 336 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBRL-15572 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBRL-15572 is a potent, selective h5-HT1D receptor antagonist.
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DescriptionBRL-15572 is a potent, selective h5-HT1D receptor antagonist with pKi of 7.9, dispalys 60-fold selectivity over h5-HT1B; shows binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively.
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In VitroBRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells.BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors.
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In VivoBRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test.BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig.
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SynonymsBRL15572 | BRL 15572
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT1A| 5-HT1D| 5-HT2A| 5-HT2B| 5-HT7
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number193611-72-2
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Formula Weight479.8696
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Molecular FormulaC25H29Cl3N2O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl
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Chemical Name1-Piperazineethanol, 4-(3-chlorophenyl)-.alpha.-(diphenylmethyl)-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Price GW, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
2. Schlicker E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):321-7.
3. De Vries P, et al. Eur J Pharmacol. 1998 Nov 27;362(1):69-72.
4. Marcoli M, et al. Br J Pharmacol. 1999 Feb;126(3):607-12.
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