Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - 5-HT Receptor - BRL-15572 dihydrochloride

BRL-15572 dihydrochloride

CAS No. 193611-72-2

BRL-15572 dihydrochloride( BRL15572 | BRL 15572 )

Catalog No. M13033 CAS No. 193611-72-2

BRL-15572 is a potent, selective h5-HT1D receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 In Stock
10MG 59 In Stock
25MG 97 In Stock
50MG 149 In Stock
100MG 223 In Stock
200MG 336 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BRL-15572 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    BRL-15572 is a potent, selective h5-HT1D receptor antagonist.
  • Description
    BRL-15572 is a potent, selective h5-HT1D receptor antagonist with pKi of 7.9, dispalys 60-fold selectivity over h5-HT1B; shows binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively.
  • In Vitro
    BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells.BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors.
  • In Vivo
    BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test.BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig.
  • Synonyms
    BRL15572 | BRL 15572
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1A| 5-HT1D| 5-HT2A| 5-HT2B| 5-HT7
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    193611-72-2
  • Formula Weight
    479.8696
  • Molecular Formula
    C25H29Cl3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl
  • Chemical Name
    1-Piperazineethanol, 4-(3-chlorophenyl)-.alpha.-(diphenylmethyl)-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Price GW, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. 2. Schlicker E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):321-7. 3. De Vries P, et al. Eur J Pharmacol. 1998 Nov 27;362(1):69-72. 4. Marcoli M, et al. Br J Pharmacol. 1999 Feb;126(3):607-12.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Haloperidol

    Haloperidol has been found to be highlt potent neuroleptic by relieving nervous through the depression of nerve function.

  • NLX-204 hydrochlorid...

    NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.

  • DOV 21947 hydrochlor...

    Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Sign In Join Free