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BRL-15572 dihydrochloride

CAS No. 193611-72-2

BRL-15572 dihydrochloride ( BRL15572;BRL 15572 )

Catalog No. M13033 CAS No. 193611-72-2

BRL-15572 is a potent, selective h5-HT1D receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRL-15572 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    BRL-15572 is a potent, selective h5-HT1D receptor antagonist.
  • Description
    BRL-15572 is a potent, selective h5-HT1D receptor antagonist with pKi of 7.9, dispalys 60-fold selectivity over h5-HT1B; shows binding affinities for 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 with pKi of 7.7, 6.1, 5.2, 6.0, 6.6, 7.4, 6.2, 5.9 and 6.3, respectively.
  • Synonyms
    BRL15572;BRL 15572
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1A; 5-HT1D; 5-HT2A; 5-HT2B; 5-HT7
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    193611-72-2
  • Formula Weight
    479.87
  • Molecular Formula
    C25H29Cl3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl
  • Chemical Name
    1-Piperazineethanol, 4-(3-chlorophenyl)-.alpha.-(diphenylmethyl)-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Price GW, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
2. Schlicker E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):321-7.
3. De Vries P, et al. Eur J Pharmacol. 1998 Nov 27;362(1):69-72.
4. Marcoli M, et al. Br J Pharmacol. 1999 Feb;126(3):607-12.
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